• Anvendelser av Norges historiske befolkningsregister 

      Thorvaldsen, Gunnar; Sommerseth, Hilde Leikny; Holden, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-14)
      Norge har et sentralt landsdekkende folkeregister som ble startet opp i 1964, og for mange personer inneholder data som går lenger tilbake. For tida bygger vi et Historisk befolkningsregister (HBR) tilbake til 1801. Målet er å konstruere en nasjonal database for også å håndtere innenlandsk migrasjon, som er dårlig dekket i de nominative kildene til langt ut på 1900-tallet. HBR bygger primært på ...
    • The Development of Microhistorical Databases in Norway A Historiography 

      Thorvaldsen, Gunnar; Holden, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-11)
      Norwegian work on microdata started out with the full count 1801 census and census and vital records from around the capital. Today, most census and ministerial records from 1801 until the mid-20th century have been scanned, transcriptions are being completed, much is encoded and made available via the websites of the Digital National Archives and UiT The Arctic University of Norway. This article ...
    • Each pregnancy linearly changes immune gene expression in the blood of healthy women compared with breast cancer patients 

      Lund, Eiliv; Nakamura, Aurelie; Snapkov, Igor; Thalabard, Jean-Christophe; Olsen, Karina Standahl; Holden, Lars; Holden, Marit (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-30)
      <p><i>Background</i>: There is a large body of evidence demonstrating long-lasting protective effect of each full-term pregnancy (FTP) on the development of breast cancer (BC) later in life, a phenomenon that could be related to both hormonal and immunological changes during pregnancies. In this work, we studied the pregnancy-associated differences in peripheral blood gene expression profiles between ...
    • The Genomic HyperBrowser: an analysis web server for genome-scale data 

      Sandve, Geir Kjetil; Gundersen, Sveinung; Johansen, Morten; Glad, Ingrid Kristine; Gunathasan, Krishanthi; Holden, Lars; Holden, Marit; Liestøl, Knut; Nygård, Ståle; Nygaard, Vegard; Paulsen, Jonas; Rydbeck, Halfdan; Trengereid, Kai; Clancy, Trevor; Drabløs, Finn; Ferkingstad, Egil; Kalaš, Matúš; Lien, Tonje Gulbrandsen; Rye, Morten Beck; Frigessi, Arnoldo; Hovig, Johannes Eivind (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      The immense increase in availability of genomic scale datasets, such as those provided by the ENCODE and Roadmap Epigenomics projects, presents unprecedented opportunities for individual researchers to pose novel falsifiable biological questions. With this opportunity, however, researchers are faced with the challenge of how to best analyze and interpret their genome-scale datasets. A powerful way ...
    • Global blood gene expression profiles following a breast cancer diagnosis - Clinical follow-up in the NOWAC post-genome cohort 

      Olsen, Karina Standahl; Holden, Marit; Thalabard, Jean-Christophe; Busund, Lill-Tove Rasmussen; Lund, Eiliv; Holden, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-08)
      <i>Objective</i> - This explorative study aimed to assess if there are any time-dependent blood gene expression changes during the first one to eight years after breast cancer diagnosis, which can be linked to the clinical outcome of the disease.<br><br> <i>Material and methods</i> - A random distribution of follow-up time from breast cancer diagnosis till blood sampling was obtained by a nested, ...
    • Lenking og kobling i Historisk befolkningsregister 

      Holden, Lars; Boudko, Svetlana; Thorvaldsen, Gunnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-14)
      Historisk befolkningsregister, HBR, er et register over den norske befolkningen fra 1801 frem til Det sentrale folkeregisteret fra 1964. Det lages ved å lenke sammen personforekomster av samme person i folketellinger og kirkebøker og koble sammen nære familiemedlemmer.<br><br> Vi viser hvordan algoritmer brukes til å finne lenker og koblinger. Vi har funnet familierelasjoner i alle de nominative ...
    • Local In Time Statistics for detecting weak gene expression signals in blood – illustrated for prediction of metastases in breast cancer in the NOWAC Post-genome Cohort 

      Holden, Marit; Holden, Lars; Olsen, Karina Standahl; Lund, Eiliv (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-10)
      Background: Functional genomics in a processual analysis cover the time-dependent changes in transcriptomics and epigenetics before diagnosis of a disease, reflecting the changes in both life style and disease processes. The aim of this paper is to explore the dynamic, time-dependent mechanisms of the metastatic processes, using blood transcriptomics and including time in a continuous manner. For ...
    • A new statistical method for curve group analysis of longitudinal gene expression data illustrated for breast cancer in the NOWAC postgenome cohort as a proof of principle 

      Lund, Eiliv; Holden, Lars; Bøvelstad, Hege; Plancade, Sandra Caroline; Mode, Nicolle; Günther, Clara-Cecilie; Nuel, Gregory; Thalabard, Jean-Christophe; Holden, Marit (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-05)
      <b>Background: </b>The understanding of changes in temporal processes related to human carcinogenesis is limited. One approach for prospective functional genomic studies is to compile trajectories of differential expression of genes, based on measurements from many case-control pairs. We propose a new statistical method that does not assume any parametric shape for the gene trajectories. <br><b>Methods:</b> ...
    • Signals of Death - Post-Diagnostic Single Gene Expression Trajectories in Breast Cancer - A Proof of Concept 

      Lund, Eiliv; Holden, Marit; Thalabard, Jean-Christophe; Rasmussen Busund, Lill-Tove; Snapkov, Igor; Holden, Lars (Chapter; Bokkapittel, 2020-12-08)
      Using the time-dependent dynamics of gene expression from immune cells in blood, we aimed to explore single gene expression trajectories as biomarkers for death after a diagnosis of breast cancer introducing a new statistical method denoted Difference in Time Development Statistics (DTDS). This shows as proof of principle that the gene expression profiles from immune cells in blood differed in the ...